RecruitingNormal Physiology
MRS Measurement of Glutamate and GABA Metabolism in Brain
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA)....
Sponsor: National Institute of Mental Health (NIMH)
You may not qualify if…
- ✕ Any current Axis 1 diagnosis
- ✕ Clinically significant laboratory abnormalities
- ✕ Positive HIV test
- ✕ Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
- ✕ History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
- ✕ Prescription psychotropic medication; drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)
- ✕ Serious medical illness as determined from H\&P or laboratory testing including Diabetes
- ✕ Inability to lie flat on camera bed for about two and a half hours
Where it's recruiting
Maryland
Bethesda
Source: ClinicalTrials.gov · NCT00109174 · last updated 2026-08-25