Effects of Treatments on Atopic Dermatitis
Eligible age
2–50 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
Background: \- Atopic dermatitis, or eczema, is a chronic skin disorder. Patients sometimes have infections with S. aureus bacteria. Researchers want to study how eczema treatments affect the number and the type of bacteria on the skin. Objectives: \- To study the effect of eczema treatments on skin bacteria. Eligibility: * Individuals between 2 and 25 years of age who have moderate to severe atopic dermatitis. * Healthy volunteers between 18 and 40 years of age with no history of eczema. Design: * Participants will be screened with a physical exam and medical history. Research samples will be collected. Skin biopsies may also be performed. * All participants will be assigned to one of several study groups. * Healthy volunteers must not have taken antibiotics in the year before the start of the study. * All participants will have regular study visits during their 1-year participation. More research samples will be collected at these visits. * Healthy volunteers may be asked to come in for a one-time follow up after the 1 year mark.
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
You may not qualify if…
- ✕ Cohorts 1 \[NO FURTHER ACCRUAL\] and 2 \[INACTIVE\]: Healthy Volunteers
- ✕ Does not meet inclusion criteria
- ✕ Any female with symptoms and/or serum hormone levels consistent with perimenopause or menopause
- ✕ Use of systemic antibiotics in 12 months preceding baseline sampling
- ✕ Use of swimming pools, hot tubs, or whirlpools in 7 days preceding baseline sampling
- ✕ Use of topical or oral complementary/alternative medicine (CAM) agents within 4 weeks of initiation of treatment
- ✕ Known allergic reaction to sulfa, beta-lactam, or tetracycline class drugs; or lidocaine or epinephrine
- ✕ Family history of toxic epidermal necrolysis
Where it's recruiting
Bethesda
Source: ClinicalTrials.gov · NCT01631617 · last updated 2026-06-24