RecruitingImpaired CognitionChemo-brainBreast Cancer
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
Eligible age
60+ yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
Sponsor: Massachusetts General Hospital
You may qualify if…
- ✓ Breast cancer patients treated with chemotherapy- Group 1 (experimental group)
- ✓ Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study
- ✓ New diagnosis histologically confirmed invasive breast cancer
- ✓ Treatment plan to include chemotherapy
- ✓ Female subjects age ≥ 60 years.
- ✓ Life expectancy ≥ 1 year
- ✓ Karnofsky Performance Score (KPS) ≥ 80
- ✓ Ability to understand and the willingness to sign a written informed consent document.
You may not qualify if…
- ✕ Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study:
- ✕ Participants with clinical or radiographic evidence of metastatic CNS disease
- ✕ Subjects with MMSE scores below 24
- ✕ Active or history of major psychiatric disorders such as schizophrenia, schizoaffective disorder, major affective disorder in mid-life, or treatment with ECT (Mild depression that is well treated with stable dose of SSRI antidepressants may be allowed).
- ✕ Substance abuse within the past 2 years
- ✕ Huntington's disease, hydrocephalus or seizure disorder
- ✕ In addition to exclusion criteria above, participants who exhibit any of the following conditions at screening will not be eligible for admission into imaging portion of the study:
- ✕ Participants with contraindications to MRI (i.e., implanted metal including pacemakers, cerebral spinal fluid shunts, aneurysm clips, artificial heart valves, ear implants or metal/foreign objects in the eyes and those with a history of claustrophobia), injuries to the eyes with metal without X-ray documentation that metal was removed
Where it's recruiting
Massachusetts
Boston · Salem
Source: ClinicalTrials.gov · NCT02290834 · last updated 2026-07-16