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RecruitingAlzheimer Disease

F 18 T807 Tau PET Imaging of Alzheimer's Disease

Eligible age

18+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

A single-center, open-label baseline controlled imaging study designed to assess whether brain tau fibril uptake of flortaucipir as measured by PET correlates with cognitive status of individuals with and without brain tau fibrils.

Sponsor: Tammie L. S. Benzinger, MD, PhD

You may qualify if…

  • ✓ 1. Male or female participants, at least 18 years of age.
  • ✓ 2. Cognitively normal, or with mild dementia, as assessed clinically
  • ✓ 3. Participant is able and willing to undergo testing (MRI or CT, PET, radioactive tracer injection, LP; for those unable to undergo an MRI, CT will be used to generate regions-of-interest).
  • ✓ 4. Pre-menopausal women will undergo a urine pregnancy test within 24 hours of drug administration.

You may not qualify if…

  • ✕ 1. Has any condition that, in the Investigator's opinion, could increase risk to the participant, limit the participant's ability to tolerate the experimental procedures, or interfere with the collection/analysis of the data (for example, participants with severe chronic back pain might not be able to lie still during the scanning procedures).
  • ✕ 2. Is deemed likely unable to perform the imaging procedures for any reason.
  • ✕ 3. Has a high risk for Torsades de Pointes or is taking medications known to prolong QT interval.
  • ✕ 4. Has hypersensitivity to F 18 T807 or any of its excipients.
  • ✕ 5. Contraindications to PET, PET-CT or MR (e.g. electronic medical devices, inability to lie still for long periods) that make it unsafe for the individual to participate.
  • ✕ 6. Severe claustrophobia.
  • ✕ 7. Currently pregnant or breast-feeding.
  • ✕ 8. For those electing to undergo the optional lumbar puncture: currently on anticoagulant of any form -

Where it's recruiting

Missouri

St Louis

Source: ClinicalTrials.gov · NCT02414347 · last updated 2026-06-08