Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.
Sponsor: MaineHealth
You may qualify if…
- ✓ Aged 18 years or older
- ✓ Admitted to the intensive care unit after cardiac arrest episode
- ✓ Unresponsive after resuscitation
You may not qualify if…
- ✕ Moribund / actively dying at the time of evaluation
- ✕ Informed consent cannot be obtained within 24 hours of resuscitation
- ✕ Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion
Where it's recruiting
Portland
Source: ClinicalTrials.gov · NCT02664831 · last updated 2025-07-18