RecruitingDiabetes Mellitus, Type 2Impaired Glucose Tolerance (IGT)Impaired Fasting Glucose (IFG)
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
HYPOTHESIS: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have distinct pathophysiologic etiologies. Therefore, therapeutic interventions designed to correct the specific underlying pathogenic abnormalities in IGT and IFG will be required to optimally prevent the progressive beta cell failure and development of overt type 2 diabetes.
Sponsor: The University of Texas Health Science Center at San Antonio
You may qualify if…
- ✓ NGT subjects will serve as controls and will be matched in age, gender, ethnicity, and BMI to IGT and IFG subjects
- ✓ 1. Male or female subjects between the ages of 18 and 65 years of age, inclusive, at Screening.
- ✓ 2. FPG \< 100 mg/dl and 2-h PG \< 140 mg/dl
- ✓ 3. BMI = 24-40 kg/m2;
- ✓ 4. Stable body weight (±4lbs) over the preceding 3 months
- ✓ 5. Subjects with no evidence of major organ system disease as determined by physical exam, history, and screening laboratory data
- ✓ 6. Females of childbearing potential with a negative pregnancy test at Screening and Treatment visits, using one of the following forms of contraception for the duration of participation in the study (i.e., until Follow-up 7-14 days post last dose):
- ✓ Oral contraceptive
You may not qualify if…
- ✕ 1. Recent (i.e., within three (3) months prior to Screening) evidence or medical history of unstable concurrent disease such as: documented evidence or history of clinically significant hematological, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, immunological, or clinically significant neurological disease.
- ✕ 2. Subjects with a family history of diabetes in a first degree relative
- ✕ 3. BMI of less than 24 or greater than 40 kg/m2
- ✕ 4. Unstable body weight (change of greater than ±4lbs over the preceding 3 months
- ✕ 5. Subjects participating in an excessively heavy exercise program
- ✕ 6. Subject with a feeding/sleeping schedule different from a daytime feeding/night time sleeping schedule
- ✕ 7. Subjects taking medications known to alter glucose metabolism (with the exception of metformin and/or pioglitazone) or which effect brain neurosynaptic function are excluded.
- ✕ 8. Subjects with evidence of major organ system disease as determined by physical exam, history, and screening laboratory data
Where it's recruiting
Texas
San Antonio
Source: ClinicalTrials.gov · NCT02969798 · last updated 2025-08-27