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RecruitingAlzheimer Disease

UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy

Eligible age

50+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer \[C-11\]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with \[C-11\]PiB-PET, and cognitive status will be the primary outcome of this imaging study.

Sponsor: University of Alabama at Birmingham

You may qualify if…

  • \- 1. Enrollment in the UAB-ADC study under a separate IRB-approved research protocol (IRB-300000169).
  • 2\. Negative urine or serum B-hCG test within 2 days of \[C-11\]PiB administration in women of child bearing potential. Women who are post-menopausal with at least 1 year since last menses or documented surgical sterilization will not require pregnancy testing.

You may not qualify if…

  • 1. Meets any exclusion criteria for the UAB-ADC study (IRB-300000169).
  • 2. Inability or contraindication for undergoing MRI and/or PET imaging
  • 3. Inability to participate in the imaging studies due to severity of dementia

Where it's recruiting

Alabama

Birmingham

Source: ClinicalTrials.gov · NCT03503331 · last updated 2025-12-11