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RecruitingMultiple Myeloma

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

Eligible age

30+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The PROMISE Study aims to establish a prospective cohort of individuals with precursor conditions to multiple myeloma, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). We will study these patients as a means to identify risk factors for progression to symptomatic multiple myeloma.

Sponsor: Dana-Farber Cancer Institute

You may qualify if…

  • Age ≥ 30 years
  • AA race (self-identified) and/or first-degree relative of a patient with a plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia, or another blood cancer.
  • Those over 18 are also eligible if they have 2 or more family members with a blood cancer

You may not qualify if…

  • \* • Persons diagnosed with cancer at any site (including hematologic cancers) with symptomatic disease requiring active therapy.
  • Persons with an already diagnosed plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia
  • First-degree relatives would not need to be identified by the participant.
  • This study includes all special populations who fall within the eligible high-risk age range, ≥ 30 years of age, including adults unable to consent, pregnant women, and prisoners. These populations will not be excluded as this is a non-therapeutic study.

Where it's recruiting

Source: ClinicalTrials.gov · NCT03689595 · last updated 2026-05-07