RecruitingPhotophobiaTraumatic Brain InjuryMigraine
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Eligible age
18–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.
Sponsor: Randy Kardon
You may qualify if…
- ✓ Healthy individuals with normal eye exam in the previous year
- ✓ Age 18-80
- ✓ Age 18-80
- ✓ Traumatic Brain Injury (TBI)
You may not qualify if…
- ✕ History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury/surgery
- ✕ Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics
- ✕ Must not be light sensitive or get migraine headaches
- ✕ TBI patients without photosensitivity or headache:
- ✕ History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and/or hypertension that are not well controlled
- ✕ Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics - Must not be light sensitive or get migraine headaches (use headache criteria from Ana if we are including headaches)
- ✕ Patients with photosensitivity from non-TBI causes Inclusion Criteria
- ✕ Age 18-80
Where it's recruiting
Iowa
Iowa City
Source: ClinicalTrials.gov · NCT03694626 · last updated 2025-11-24