RecruitingAlzheimer DiseaseDementiaMild Cognitive Impairment
OCT Angiography and NRAI in Dementia
Eligible age
55+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.
Sponsor: Oregon Health and Science University
You may qualify if…
- ✓ Physician-confirmed diagnosis of probable Alzheimer's disease
- ✓ Mild dementia, as defined by score of 20 or greater on the Mini-Mental State Exam, or score of 15 or greater on the Montreal Cognitive Assessment, or Clinical Dementia Rating Scale score of 1.
- ✓ Age older than 55 years.
- ✓ Able to comply with study procedures
- ✓ Corrected visual acuity at least 20/400 in either eye.
- ✓ Has a legally authorized representative who can sign study consent form and accompany the participant to the OCT study visit.
- ✓ Age older than 55 years
- ✓ Able to comply with study procedures
You may not qualify if…
- ✕ Non-Alzheimer's disease related primary neurologic disease affecting the central nervous system (i.e. multiple sclerosis, Parkinson's disease)
- ✕ Evidence on ophthalmological exam within the last year of other ocular diseases or pathology that would confound the assessment of dementia (e.g. glaucoma, diabetic or hypertensive retinal disease, amblyopia, etc.)
- ✕ Media opacity such as cataract, corneal scar, or vitreous opacity that could interfere with retinal imaging.
- ✕ Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber intraocular lens implantation
- ✕ Inability to maintain stable fixation for OCT imaging or provide informed consent
- ✕ Spherical equivalent refractive error greater than +3 or -7 diopters, or astigmatism magnitude of greater than 2 diopters.
- ✕ Diabetes for more than 10 years or hemoglobin A1C level of \> 10 within the 180 days prior to OCT scanning.
- ✕ Uncontrolled hypertension. : SBP \> 170 or DBP \> 100
Where it's recruiting
Oregon
Portland
Source: ClinicalTrials.gov · NCT03761381 · last updated 2025-09-12