Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ Men and women Veterans with central sleep apnea, defined as Apnea Hypopnea Index (AHI)\>15/hour with CAHI\>5/hour, will be included in the experiments
You may not qualify if…
- ✕ less than 18 years old
- ✕ pregnant or breastfeeding female
- ✕ have severe respiratory disease that require to be on oxygen
- ✕ recent health event that may affect the ability to participate in the study,
- ✕ Body Mass Index (BMI) is \>40 kg/m2
- ✕ significant insomnia
- ✕ mental instability
- ✕ recent health event that may affect sleep
Where it's recruiting
Detroit
Source: ClinicalTrials.gov · NCT04118387 · last updated 2026-07-20