RecruitingMild or Moderate Asthma With Allergic Sensitization
5HTP Regulation Of Asthma In Children
Eligible age
8–18 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The purpose of this study is to learn more about if taking a supplement called 5-hydroxytryptophan (5HTP) can improve breathing and anxiety symptoms related to asthma. To help learn more subjects will either be assigned to a group that is taking the supplement (5HTP) or a group that is taking a placebo. This will be decided randomly. Later in the study subjects will crossover to the other group.There are 5 study visits over the course of about 12 weeks.
Sponsor: Indiana University
You may qualify if…
- ✓ Age 8-18 Years of Age
- ✓ Mild to Moderate Asthma based on ATS guidelines
- ✓ Positive Allergy Test (positive skin or serum IgE)
- ✓ Weight ≥ 70 lbs (32 kg)
- ✓ CES-DC cut-off ≥ 15 (total score range is 0 to 60) or SCARED cut-off
- ✓ 25 (total score range is 0 to 142)
- ✓ Ability to comply with study visits and study procedures
- ✓ Informed Consent by participant and if applicable the parent or legal guardian
You may not qualify if…
- ✕ Currently taking a SSRI
- ✕ Taking a leukotriene inhibitor (montelukast, Zileuton)
- ✕ Severe Asthma Based on ATS Guidelines
- ✕ Taking a biologic medication (omalizumab, mepolizumab, benralizumab, dupilumab)
- ✕ Medical History of Adverse Reaction to 5HTP
- ✕ Physical findings that would compromise the safety of the study or the quality of the study data
Where it's recruiting
Indiana
Indianapolis
Source: ClinicalTrials.gov · NCT04160910 · last updated 2026-03-02