RecruitingPain
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
Eligible age
21–45 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Sponsor: University of Florida
You may qualify if…
- ✓ Individuals fluent in English will participate.
- ✓ Must report recreational use of opioids.
- ✓ Be within 20% of their ideal body weight.
- ✓ Are not currently experiencing chronic pain (pain on most days during the past 3 months)
- ✓ Have a systolic blood pressure of \<=140 and diastolic blood pressure of \<= 90, and a heart rate \<= 90 beats per minute.
- ✓ Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications.
You may not qualify if…
- ✕ Significant current physical disease or major psychiatric disorder.
- ✕ No self-reported current interest in drug abuse treatment.
- ✕ Women who are pregnant or nursing.
- ✕ Any comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine.
- ✕ Any conditions that preclude safety in the MRI scanner, such as: implanted electrical devices (e.g., cardiac pacemaker, neurostimulator); implanted metallic clips or pins (e.g., aneurysm clip); a history of working with metal (unless able to demonstrate participant is MRI safe), and claustrophobia.
Where it's recruiting
Florida
Gainesville
Source: ClinicalTrials.gov · NCT04218409 · last updated 2026-01-14