Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This phase II trial studies how well radiation therapy works for the treatment of gastrointestinal cancer that are spreading to other places in the body (metastatic). Radiation therapy uses high energy x-rays to kill cancer cells and shrink tumors. This trial is being done to determine if giving radiation therapy to patients who are being treated with immunotherapy and whose cancers are progressing (getting worse) can slow or stop the growth of their cancers. It may also help researchers determine if giving radiation therapy to one tumor can stimulate the immune system to attack other tumors in the body that are not targeted by the radiation therapy.
Sponsor: University of California, San Francisco
You may qualify if…
- ✓ 1. Patients must have a histologically, cytologically, or radiographically confirmed metastatic gastrointestinal (GI) malignancy (esophageal, gastroesophageal, gastric, small intestine, hepatocellular, pancreaticobiliary, colorectal, or anal cancer).
- ✓ 2. Patients must be receiving immunotherapy (checkpoint inhibitor or CTLA4 inhibitor) with overall response of progressive disease by RECIST criteria.
- ✓ 3. Patients must have at least one metastasis which is progressing as per RECIST criteria.
- ✓ 4. Patients must have 1-5 sites of disease meeting standard-of-care indications for palliative radiation therapy as adjudicated by the treating radiation oncologist. For example:
- ✓ Symptomatic disease causing pain, bleeding, dyspnea, dysphagia, or nausea
- ✓ At-risk for neurologic, respiratory, cardiovascular, gastrointestinal, musculoskeletal, or hepatobiliary compromise
- ✓ 5. Evaluation by a radiation oncologist within 28 days of study registration.
- ✓ 6. Must have adequate organ function to administer radiation therapy and immunotherapy as per standard of care.
You may not qualify if…
- ✕ 1. Enrollment on immunotherapy clinical trial for which radiation therapy is not permitted.
- ✕ 2. Administration of radiation therapy within 4 weeks prior to study enrollment.
- ✕ 3. Treatment with systemic corticosteroids or other immunosuppressive medications which would significantly diminish the effect of immunotherapy as judged by the treating physician.
- ✕ 4. Radiation therapy is contraindicated as adjudicated by the radiation oncologist.
Where it's recruiting
San Francisco · Walnut Creek
Source: ClinicalTrials.gov · NCT04221893 · last updated 2026-08-14