SAMe Trial for Patients With Alcoholic Cirrhosis
Eligible age
18–70 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The proposed of this randomized, double blinded, placebo-controlled study is to assess the effect of SAMe compared to placebo in patients with alcoholic cirrhosis Child Class A and B. The primary objective of the study is to test relationship between SAMe (S-adenosylmethionine) supplement on liver function. The hypothesis is that SAMe supplement will improve liver function in patients with alcoholic liver disease. The improvement in liver function will lead to the reduction in all-cause mortality in patients with alcoholic cirrhosis in those who receive SAMe supplement when compared to those receiving placebo.
Sponsor: Indiana University
You may qualify if…
- ✓ 1. Evidence of cirrhosis as per clinical signs and/or noninvasive transient elastography (Fibroscan®), computed tomography, magnetic resonance imaging including MRI elastography compatible with cirrhosis and/or histopathology by biopsy and
- ✓ 2. subjects with clinical presentation either in Child Class A or B at the time of enrollment
- ✓ 3. individuals 18 to 70 years old and may or may not consume alcohol during study.
- ✓ ) individuals 18 to 70 years old (2) able to provide informed consent (3) subjects do not consume any alcohol or those who drink \< 50 grams per day on average in women and \< 80 grams per day on average in men (4) subjects are healthy without underlying acute or chronic medical conditions.
You may not qualify if…
- ✕ 1. Active infection as evidenced by positive urine culture, blood culture, or pneumonia,
- ✕ 2. Known co-existing infection with hepatitis C, hepatitis B, or HIV
- ✕ 3. Significant systemic or major illness including chronic obstructive pulmonary disease, congestive heart failure, and renal failure that in the opinion of the Investigator would preclude the patient from participating in and completing the study
- ✕ 4. Gastrointestinal bleeding within the prior 28 days3
- ✕ 5. Participation in another investigational drug, biologic, or medical device trial within 30 days prior to screening
- ✕ 6. Women who are pregnant, may become pregnant, or nursing
- ✕ 7. Presence of any other disease or condition that is interfering with the absorption, distribution, metabolism, or excretion of SAMe such as those with gastric bypass surgery
- ✕ 8. Subjects with history of/diagnosis of hepatocellular carcinoma
Where it's recruiting
Los Angeles
Indianapolis
Source: ClinicalTrials.gov · NCT04250259 · last updated 2026-03-31