RecruitingCoronavirus Infection (COVID-19)Pulmonary Arterial HypertensionUrinary Tract Infections in Children

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Eligible age

0–20 yrs

Accepts

All genders

Locations

35 states

Healthy volunteers

Yes

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About this study

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.

Sponsor: Duke University

You may qualify if…

✓ 1. Participant is \< 21 years of age
✓ 2. Parent/ Legal Guardian/ Adult Participant can understand the consent process and is willing to provide informed consent/HIPAA:
✓ 3. (a) Participant is receiving one or more of the study drugs of interest at the time of enrollment or (b) Participant is NOT receiving one or more of the study drugs of interest but is SARS-COV-2 positive within 60 days prior to enrollment

You may not qualify if…

✕ 1. Participant has a known pregnancy
✕ Below exclusion criteria apply only to:
✕ Participants receiving one or more of the study drugs of interest at the time of enrollment, DOI administration or PK sampling: (Refer to DOI specific appendices for details on enrollment cohort specifications and additional eligibility criteria)
✕ 2. Has had intermittent dialysis within previous 24 hours
✕ 3. Has had a kidney transplant within previous 30 days
✕ 4. Has had a liver transplant within previous 1 year
✕ 5. Has had a stem cell transplant within previous 1 year
✕ 6. Has had therapeutic hypothermia within previous 24 hours