Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Eligible age
35–70 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
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About this study
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.
Sponsor: University of Minnesota
You may qualify if…
- ✓ Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
- ✓ Premenopausal 35-49 years of age
- ✓ Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
- ✓ Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL
You may not qualify if…
- ✕ Current nicotine/tobacco use within the past six months
- ✕ Are diabetic or asthmatic
- ✕ Have diagnosed significant carotid stenosis
- ✕ Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
- ✕ Have existing metabolic or endocrine abnormities
- ✕ Take any heart/blood pressure medications that are determined to interfere with study outcomes
- ✕ IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
- ✕ Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
Where it's recruiting
Minneapolis
Source: ClinicalTrials.gov · NCT04439370 · last updated 2026-01-08