RecruitingSpinal Cord InjuriesUrinary Incontinence

Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries

Eligible age

18–70 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

The goal of this study is to determine whether administration of sildenafil will decrease urine leakage in patients with spinal cord injuries.

Sponsor: The University of Texas Medical Branch, Galveston

✓ Adults with spinal cord injury (SCI), 18-75 years of age, at the time of consent
✓ Have urinary incontinence (UI), with at least 3 leakage episodes/week
✓ Have urodynamics assessment on file with their provider in past 3 years. If no historical data on file, subject may complete prior to study visit 1.
✓ Willing and able to comply with study procedures
✓ Willing and able to provide written informed consent

✕ In phone prescreen, delighted or pleased with current quality of life due to urinary symptoms.
✕ Indwelling catheter
✕ History of greater than 4 urinary tract infections per year
✕ Multiple sclerosis
✕ Significant heart, liver, kidney, pulmonary, blood, autoimmune or peripheral vascular disease
✕ Systolic blood pressure \<90 or \>170, diastolic blood pressure \<50 or \>110 after repeated evaluation with proper cuff. This range is the acceptable range stated in the prescribing information for sildenafil (\>90/50 and \<170/110)
✕ Active cancer
✕ HIV, Hepatitis B, or Hepatitis C

College Station · Galveston

Source: ClinicalTrials.gov · NCT04565925 · last updated 2025-12-16