Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer
Eligible age
18+ yrs
Accepts
Women
Locations
3 states
Healthy volunteers
No
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About this study
This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer. Radiation therapy uses high energy protons or x-rays to kill tumor cells and shrink tumors. Using quality of life questionnaires and adverse event assessments may help doctors learn whether proton radiation therapy is associated with lower acute gastrointestinal toxicities at the end of treatment compared to intensity modulated radiation therapy in patients with endometrial or cervical cancer.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ Histologically confirmed diagnosis of cervical or endometrial cancer
- ✓ Must have undergone an open or robotic hysterectomy (total abdominal, vaginal, radical, or total laparoscopic) for carcinoma of the cervix or endometrium
- ✓ History and physical prior to registration
- ✓ Documentation of history of:
- ✓ Smoking status
- ✓ Pelvic infection
- ✓ Pelvic inflammatory disease
- ✓ Endometriosis
You may not qualify if…
- ✕ Receiving external beam boost dose during RT
- ✕ Distant metastases
- ✕ Gross disease at time of RT
- ✕ Histology of endometrial stromal sarcoma, leiomyosarcoma, melanoma or small cell carcinomas
- ✕ Patients who exceed the weight/size limits of the treatment table
- ✕ Positive or close surgical margins (=\< 3 mm)
- ✕ Prior RT to the pelvis
- ✕ Planned to receive inguinal node RT
Where it's recruiting
Source: ClinicalTrials.gov · NCT04567771 · last updated 2026-08-19