RecruitingStroke, Acute
WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)
Eligible age
18+ yrs
Accepts
All genders
Locations
3 states
Healthy volunteers
No
See if you qualify for this study
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About this study
The WE-TRUST study is a multi-center randomized clinical trial to assess the impact of a Direct to Angio Suite (DTAS) workflow on stroke patient outcomes.
Sponsor: Philips Clinical & Medical Affairs Global
You may qualify if…
- ✓ Subject is 18 years of age or older, or of legal age to give informed consent per state or national law.
- ✓ Baseline NIHSS score obtained prior to randomization must be equal or higher than 10 points.
- ✓ Subjects with no significant pre-stroke functional disability (modified Rankin scale 0 - 2).
- ✓ Subjects suspected of acute ischemic stroke with an estimated arrival time at a stroke center (clinical investigational site participating in this study) \< 6 hours from symptom onset OR wake-up stroke with time last known well of \< 12 hours and symptoms discovered within 6 hours from arrival time at a stroke center. Symptom onset is defined as point in time the patient was last known well (at baseline).
- ✓ Informed consent obtained from patient or his or her legally designated representative (if locally required).
- ✓ Angiography suite immediately available.
- ✓ Endovascular treatment team immediately available (Neurologist, Neurointerventionalist, Anesthesiologist, Nursing, Technicians as per local standard practice)
You may not qualify if…
- ✕ Clinical exclusion criteria:
- ✕ Known hemorrhagic diathesis, coagulation factor deficiency, or oral anticoagulant therapy with INR \> 3.0
- ✕ Known baseline platelet count \< 30.000/μL
- ✕ Baseline blood glucose of \< 50mg/dL (\< 2.78mmol/l)
- ✕ For patients receiving thrombolysis: severe, sustained hypertension (SBP \> 185 mm Hg or DBP \> 110 mm Hg). Note: If the blood pressure can be successfully reduced and maintained at the acceptable level using AHA/ASA guidelines recommended medication (including IV antihypertensive drips), the patient can be enrolled.
- ✕ Patients from a transfer center (Primary Stroke Center) with a CT/MR that is not required to be redone in the Comprehensive Stroke Center as per discretion of the physician or per local standards (e.g. CT/MR less than 90 minutes old).
- ✕ Patients in coma (NIHSS item of consciousness \>1) defined as totally unresponsive; responding only with reflexes or being areflexic (Intubated patients for transfer could be randomized only in case an NIHSS is obtained by a neurologist prior transportation).
- ✕ Patients with extreme vomiting
Where it's recruiting
Source: ClinicalTrials.gov · NCT04701684 · last updated 2026-03-05