Neural Correlates of Stress and Perceived Control in Adolescent Depression
Eligible age
14–18 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
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About this study
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.
Sponsor: Mclean Hospital
You may qualify if…
- ✓ Inclusion Criteria: All Participants
- ✓ 1. Females of all ethnic origins See Section: Inclusion of Women and Minorities);
- ✓ 2. Ages 14-18 (See Section: Inclusion of Children);
- ✓ 3. Written informed assent/consent from adolescent and parent/guardian (if under age 18);
- ✓ 4. English as a first language or English fluency;
- ✓ 5. Right handed111;
- ✓ 6. Personal cell-phone (for Ecological Momentary Assessment \[EMA\]) 7 All participants will be in the follicular phase of their menstrual cycle when completing the functional magnetic resonance imaging (fMRI) study session
- ✓ 1. Meet Diagnostic Statistical Manual-5th edition (DSM-5) diagnostic criteria for major depressive disorder (as diagnosed with the KSADS)
You may not qualify if…
- ✕ Exclusion Criteria: All Participants
- ✕ 1. History of head trauma with loss of consciousness;
- ✕ 2. History of seizure disorder;
- ✕ 3. Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease;
- ✕ 4. History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine);
- ✕ 5. History of use of dopaminergic drugs (including methylphenidate);
- ✕ 6. Use of hormonal replacement therapy, anabolic steroids, or hormonal contraception;
- ✕ 7. Clinical or laboratory evidence of hypothyroidism;
Where it's recruiting
Belmont
Source: ClinicalTrials.gov · NCT04788524 · last updated 2026-05-19