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RecruitingAtrial FibrillationObstructive Sleep Apnea

Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

Eligible age

18–75 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) in OSA patients without atrial fibrillation (AF).

Sponsor: Tulane University

You may qualify if…

  • ✓ Group A: 10 patients 18-75-year-old With mild OSA (5\<AHI\<15), confirmed by polysomnography. No previous AF diagnosis on the medical chart
  • ✓ Group B: 10 patients 18-75-year-old With moderate OSA (15\<AHI\<30), confirmed by polysomnography. No previous AF diagnosis on the medical chart
  • ✓ Group C: 10 patients 18-75-year-old With severe OSA (AHI\>30), confirmed by polysomnography. No previous AF diagnosis on the medical chart
  • ✓ Group D (mild OSA+ AF): 10 patients 18-75-year-old With mild OSA (5\<AHI\<15), confirmed by polysomnography. Previous AF diagnosis
  • ✓ In this group, patients with AF and OSA who already have done MRI might be included.
  • ✓ Group E (severe OSA +AF): 10 patients 18-75-year-old With severe OSA (AHI\>30), confirmed by polysomnography. Previous AF diagnosis
  • ✓ \*In this group, patients with AF and OSA who already have done MRI might be included.
  • ✓ Group F (Control): 10 Patients 18-75-year-old No previous OSA and/or AF Diagnosis on the medical chart

You may not qualify if…

  • ✕ History of chronic heart failure (LVEF \< 50%), AF, myocardial infarction, valvular disease.
  • ✕ Prior cardiac or chest surgery.
  • ✕ Other advanced pulmonary disease (severe Chronic Obstructive Pulmonary Disease (COPD) or asthma, pulmonary hypertension) or central sleep apnea.
  • ✕ Contraindications to DE-MRI (e.g. allergy to gadolinium, pacemakers, defibrillators (ICD's), other devices/implants contraindicated for MRI, glomerular filtration rate \<30 ml/min, etc.).
  • ✕ Pregnancy.
  • ✕ Inability to give informed consent.

Where it's recruiting

Louisiana

New Orleans

Source: ClinicalTrials.gov · NCT04814420 · last updated 2026-06-15