RecruitingSolid Tumor, AdultNon-small Cell Lung CancerMelanoma

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Eligible age

18+ yrs

Accepts

All genders

Locations

10 states

Healthy volunteers

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

Check my eligibility →

About this study

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of KIN-2787 in adults with BRAF/NRAS-mutated advanced or metastatic solid tumors.

Sponsor: Pierre Fabre Medicament

You may qualify if…

✓ Provide written informed consent prior to initiation of any study-specific procedures.
✓ Metastatic or advanced stage solid tumor
✓ Known BRAF Class I, Class II, or Class III alteration or melanoma with an NRAS mutation as confirmed by previous genomic analysis of tumor tissue or ctDNA.
✓ Measurable (Part A and B) or evaluable (Part A only) disease by RECIST v1.1.
✓ ECOG performance status 0-1
✓ Adequate organ function, as measured by laboratory values (criteria listed in protocol).
✓ Able to swallow, retain, and absorb oral medications.

You may not qualify if…

✕ Known participants who have received local therapy with either surgery and/or radiation therapy (participants with asymptomatic untreated brain metastasis may be eligible if met with certain criteria)
✕ In Part B Dose Expansion, previous treatment with any approved or in-development small molecule BRAF-, MEK-, or MAPK-directed inhibitor therapy.
✕ GI tract disease causing an inability to take oral medication, malabsorption syndrome, requirement for intravenous alimentation, or uncontrolled inflammatory GI disease.
✕ Active, uncontrolled bacterial, fungal, or viral infection.
✕ Participant with a positive test result for SARS-CoV2 infection, is known to have asymptomatic infection or is suspected of having SARS-CoV2, is excluded
✕ Women who are lactating or breastfeeding, or pregnant.
✕ Participants with any other active treated malignancy within 3 years prior to enrollment
✕ Complete inclusion and exclusion criteria are listed in the clinical study protocol.