RecruitingObsessive-Compulsive Disorder
Individually Targeted Neuromodulation for Contamination-based OCD
Eligible age
18–55 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
Patients with obsessive-compulsive disorder (OCD) experience a wide array of different types of obsessions and compulsions. However, current treatments for OCD employ a "one size fits all" approach and are used for all patients regardless of symptom type. In this project, the investigators propose to investigate whether a novel method of transcranial magnetic stimulation specifically reduces contamination/washing symptoms - one of the most common types of OCD.
Sponsor: Mclean Hospital
You may qualify if…
- ✓ 1. male or female age 18-55 years old
- ✓ 2. DSM-5 diagnosis of OCD as primary presenting disorder
- ✓ 3. CONTAM as the predominant symptom dimension (i.e., Dimension 4 (CONTAM symptoms) is the highest score on the Dimensional Yale-Brown Obsessive Compulsive Scale (D-YBOCS); participants with more than one Dimension as highest score will still be eligible as long as Dimension 4 is one of these)
- ✓ 4. score of ≥ 8 on Dimension 4 of the D-YBOCS
- ✓ 5. taking no psychiatric medications or on a stable dose of an SSRI, clomipramine, SNRI, or second generation antipsychotic for at least 4 weeks prior to enrollment. Use of PRN benzodiazepines will be permitted as long as the dose/usage has not changed significantly leading up to enrollment. No medication changes will be permitted during the study
- ✓ 6. have not initiated a new course of exposure and response prevention (ERP) therapy within 4 weeks of enrollment (ongoing ERP will be permitted if initiated more than 8 weeks before enrollment).
You may not qualify if…
- ✕ 1. positive urine drug screen (other than prescribed benzodiazepines)
- ✕ 2. use of psychiatric medications other than permitted above
- ✕ 3. substance use disorder in the last 3 months (with the exception of nicotine)
- ✕ 4. history of schizophrenia, bipolar disorder, autism, Tourette's syndrome (current and past history of depressive, anxiety, and eating disorders permitted as long as OCD is considered the primary disorder)
- ✕ 5. active suicidal ideation over the week prior to screening (as indicated by answering yes to questions 1 or 2 on the C-SSRS)
- ✕ 6. history of traumatic brain injury, seizure disorder, neurodegenerative disease, or other organic brain disease
- ✕ 7. pregnancy or lactating
- ✕ 8. contraindication to MRI scanning or TMS
Where it's recruiting
Massachusetts
Belmont
Source: ClinicalTrials.gov · NCT05048251 · last updated 2024-03-15