RecruitingPre-diabetesObesity
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
Eligible age
35–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will comprehensively analyze glucose homeostasis in prediabetic patients treated for 14 weeks with mirabegron, tadalafil or both drugs as compared to a placebo.
Sponsor: Philip Kern
You may qualify if…
- ✓ Hemoglobin A1C between 5.7 and 6.4
- ✓ Body mass index between 27 and 45
You may not qualify if…
- ✕ Diabetes
- ✕ Chronic use of any antidiabetic medications
- ✕ Any unstable medical condition
- ✕ Use of steroids or daily use of NSAIDS
- ✕ History of chronic inflammatory conditions
- ✕ Use of anticoagulants
- ✕ Contraindications to the use of mirabegron or tadalafil
- ✕ Any condition deemed risky by the study physician
Where it's recruiting
Kentucky
Lexington
Source: ClinicalTrials.gov · NCT05051436 · last updated 2026-02-03