RecruitingEndometriosis
Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
Eligible age
18–45 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Sponsor: Penn State University
You may qualify if…
- ✓ Women between the ages of 18 and 45 years with endometriosis (diagnosis by prior laparoscopy by subject's own physician \<10 years prior, and reported by the subject to the researchers)
- ✓ Tylenol if the subject has acute pain is allowed
- ✓ IUD contraceptive use (copper or levonogestrel) is allowed
You may not qualify if…
- ✕ Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
- ✕ Diabetes (HbA1C .6.5%)
- ✕ BP\>140/90
- ✕ Taking pharmacotherapy that could alter peripheral vascular control (e.g. insulin sensitizing, cardiovascular medications)
- ✕ Pregnancy
- ✕ Breastfeeding
- ✕ Taking illicit and/or recreational drugs
- ✕ Abnormal liver function
Where it's recruiting
Connecticut
New Haven
Source: ClinicalTrials.gov · NCT05059626 · last updated 2024-11-05