EPPIC: Easing Pelvic Pain Interventions Clinical Research Program
Eligible age
18–70 yrs
Accepts
All genders
Locations
3 states
Healthy volunteers
No
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About this study
The EPPIC (Easing Pelvic Pain Interventions Clinical Research Program) study evaluates an ultra-brief, 4 session cognitive behavioral pain treatment transdiagnostic in design for urologic chronic pain syndrome (UCPPS) with clinical and practical advantages over existing behavioral therapies whose length and focus limits their adoption by clinicians and coverage for mechanistically similar comorbidities. A theoretically informed, practical, empirically grounded approach will systematically unpack CBT's working mechanisms, clarify for whom it works, ease dissemination, appeal to patients, providers, payers, and policy makers in the COVID-19 era favoring low resource intensity treatments, and reduce cost and inefficiencies associated with high intensity therapies whose complexity, length, and scarcity restricts uptake and impact.
Sponsor: State University of New York at Buffalo
You may qualify if…
- ✓ Ages 18-70 years (inclusive)
- ✓ Male or female
- ✓ All genders, races, ethnic groups
- ✓ MD-confirmed diagnosis of IC/BPS or CP/CPPS by study urologist or urogynecologist
- ✓ Pelvic pain including uncomfortable sensations of pressure or discomfort that are not described as outright pain) of at least six months duration
- ✓ Pelvic pain intensity of at least moderate severity (defined as 3 or greater on a 0-10 Numerical Rating Scale and causes life interference weekly and limit(s) participant's life or work-related activities, general activity level, and/or enjoyment of life) over the past 3 months.
- ✓ Ability to understand and provide informed consent
- ✓ Either not taking medications or if taking medications willing to refrain from starting new medications until after the initial 2-week pre-treatment baseline period ends unless medically necessary.
You may not qualify if…
- ✕ Presence of a neurological condition (e.g., MS, Parkinson's disease, paraplegia) affecting the bladder
- ✕ The presence of a symptomatic urethral stricture (males only)
- ✕ History of cystitis caused by tuberculosis or radiation or chemotherapies
- ✕ Participant has been diagnosed and treated for a pelvic-related malignancy (colon, bladder, prostate, ovarian, endometrial, uterine, testicular, penile, cervical, vaginal, or rectal cancer)
- ✕ Participant has a medical condition(s) whose nature or severity (unstable, life threatening, etc.) would influence adversely the conduct of the clinical trial, confound interpretation of study results, and/or compromise volunteer safety and engagement with study demands.
- ✕ Gross cognitive impairment, deafness, blindness, vision problems (severe), hearing problems (severe)
- ✕ Has a major psychiatric disorder which would impede conduct of the clinical study. These clinical disorders would include but are not limited to major depression with a high risk of suicidal behavior (i.e. intent or plan), current or recent (within the past 3 months) history of alcohol or substance abuse/dependence, a lifetime history of schizophrenia or schizoaffective disorder; or organic mental disorder
- ✕ Current involvement in psychotherapy directed specifically toward relief of urological symptoms
Where it's recruiting
Source: ClinicalTrials.gov · NCT05127616 · last updated 2026-10-13