Interpretation Bias as a Mechanism of Treatment Response in OCD
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I. Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.
Sponsor: Mclean Hospital
You may qualify if…
- ✓ 1\) OCD Institute patients
- ✓ 2\) adults (\> 18 years old)
- ✓ 3\) able to complete a computer task for 20 minutes
- ✓ 4\) consent to main OCD Institute study protocol
- ✓ 5\) primary diagnosis of OCD (as measured by a score of \>16 on the Y-BOCS and a clinical diagnosis of OCD by their treatment team
- ✓ 6\) score of \>131 on the Obsessive Beliefs Questionnaire-44 at admission \[which is 1 SD above the mean score of the non-clinical sample reported in the original validation paper by the Obsessive Compulsive Cognitions Working Group (2005)\]
You may not qualify if…
- ✕ 1\) Currently experiencing acute symptoms of psychosis
- ✕ 2\) Psychotic disorder diagnosis
Where it's recruiting
Belmont
Source: ClinicalTrials.gov · NCT05224414 · last updated 2026-05-18