RecruitingRight Bundle-Branch BlockHeart FailureHis-bundle Pacing

His-Bundle Corrective Pacing in Heart Failure

Eligible age

18+ yrs

Accepts

All genders

Locations

10 states

Healthy volunteers

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

Check my eligibility →

About this study

The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).

Sponsor: University of Rochester

You may qualify if…

✓ Age 18 years or older (no upper age limit)
✓ Optimal medical therapy for heart failure by current guidelines
✓ Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:
✓ New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR
✓ NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR
✓ NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)

You may not qualify if…

✕ Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization
✕ Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology
✕ Unable or unwilling to follow study protocol
✕ Less than 12 months life expectancy at consent
✕ Pregnancy or planned pregnancy during duration of the study
✕ On heart transplant list or likely to undergo heart transplant