Modulating Exercise Dosage to Improve Concussion Recovery
Eligible age
13–18 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
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About this study
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.
Sponsor: University of Colorado, Denver
You may qualify if…
- ✓ 13-18 years of age
- ✓ Post-Concussion Symptom Scale (PCSS) score \>10 to ensure participants are not recovered by enrollment
- ✓ Concussion diagnosis by a sports medicine physician
You may not qualify if…
- ✕ Pre-existing neurological disorders
- ✕ Exercise contraindications
- ✕ Concussion \<6 months before enrollment (excluding the current injury)
Where it's recruiting
Aurora
Boston · Cambridge
Source: ClinicalTrials.gov · NCT05434130 · last updated 2026-05-06