InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
Eligible age
All ages
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal. * The ultimate goal is to identify novel markers of early detection and risk stratification to drive potential therapeutic approaches to intercept progression to cancer.
Sponsor: Dana-Farber Cancer Institute
You may qualify if…
- ✓ Participants to be included in this study include the following (note that this list is not comprehensive but gives examples of precursor conditions for each organ type):
- ✓ 1-Hereditary risk for cancer including
- ✓ Carriers of known or previously unrecognized pathogenic germline variants of cancer predisposing genes
- ✓ Individuals with personal or family history suggestive of elevated cancer risk (this may include individuals who have negative genetic testing results or have not elected to undergo testing)
- ✓ Individuals with a clinically based diagnosis of a Cancer Predisposition Syndrome (examples, neurofibromatosis, Fanconi Anemia, Ataxia-Telangiectasia)
- ✓ Hereditary Cancer Prediction Model-based elevated cancer risk
- ✓ Others at risk for specific cancers by virtue of exposure, obesity, gender, race and ethnicity, HPV exposure (for H\&N cancer for example), etc.
- ✓ Exposed High Risk including
You may not qualify if…
- ✕ There are no exclusion criteria for the study.
- ✕ Note: Patients with prior cancer history are allowed to participate. Patients with prior history of cancer or non-metastatic localized cancers (such as skin cancer or localized prostate cancer) are allowed to be enrolled. Patients enrolled in clinical trials or receiving therapy for precursor diseases are NOT excluded from this study.
Where it's recruiting
Boston
Source: ClinicalTrials.gov · NCT05463796 · last updated 2025-08-07