RM1 Project 2 - tAN fMRI
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone. Within the MRI scanner, each participant will be connected to a series of electrodes that stimulate 4 targets (ABVN only, ATN only, ABVN plus ATN, and Sham).
Sponsor: Medical University of South Carolina
You may qualify if…
- ✓ Age 18-65
- ✓ Have the capacity and ability to provide one's own consent and sign the informed consent document
You may not qualify if…
- ✕ Contraindicated for MRI.
- ✕ Any current or recent untreated medical, neurological, or psychiatric conditions
- ✕ Metal implant devices in the head, heart or neck.
- ✕ History of brain surgery.
- ✕ History of myocardial infarction or arrhythmia, bradycardia.
- ✕ Personal or family history of seizure or epilepsy or personal use of medications that substantially reduce seizure threshold (e.g., olanzapine, chlorpromazine, lithium).
- ✕ Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- ✕ Individuals suffering from frequent/severe headaches.
Where it's recruiting
Charleston
Source: ClinicalTrials.gov · NCT05487664 · last updated 2025-12-18