RecruitingHepatobiliary CancerPancreatic CancerHepatocellular Carcinoma
Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
This is a prospective pilot protocol investigating whether ctDNA detection be improved by sampling the cancer draining vein versus the standard practice of sampling from a peripheral vein in patients who are undergoing biopsies for hepatobiliary and pancreatic cancers.
Sponsor: University of California, Irvine
You may qualify if…
- ✓ 18 years of age or older
- ✓ Have or are undergoing work-up for hepatobiliary and/or pancreatic carcinoma (such as hepatocellular carcinoma, cholangiocarcinoma, ampullary carcinoma, pancreatic carcinoma)
- ✓ Scheduled for an image-guided percutaneous or trans-jugular biopsy of a lesion
- ✓ Must be able to provide a written informed consent
You may not qualify if…
- ✕ Patients unable to hold reasonably still on a procedure table or hold their breath during imaging or needle passes
- ✕ Patients with a gross body weight over 375 pounds (upper limit of the CT and angiography tables)
- ✕ Patients with uncorrectable coagulopathy
- ✕ Platelet count \< 30,000/ul
- ✕ International Normalized (INR) \> 1.5
- ✕ Patients with moderate to severe ascites who cannot undergo trans-jugular biopsy or sufficient drainage
- ✕ No clear reachable target for percutaneous or trans-jugular biopsy
- ✕ Patient who cannot have a peripheral blood draw for ctDNA
Where it's recruiting
California
Orange
Source: ClinicalTrials.gov · NCT05497531 · last updated 2026-08-31