The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Eligible age
25–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.
Sponsor: Adrian Vella
You may qualify if…
- ✓ We will recruit up to 20 weight-stable, subjects with type 2 diabetes
- ✓ BMI ≥ 28 Kg/M2
- ✓ Diabetes is managed by diet alone or a combination of oral agents
You may not qualify if…
- ✕ History of prior upper abdominal surgery e.g. gastric banding, pyloroplasty, vagotomy.
- ✕ Active systemic illness or malignancy.
- ✕ Symptomatic macrovascular or microvascular disease.
- ✕ Contraindications to MRI (e.g. metal implants, claustrophobia).
- ✕ Hematocrit \< 35%
- ✕ TSH \< 0.4 or \> 5.5.
- ✕ Consumption of \> 2 alcohol drinks per day or \> 14 per week or a positive AUDIT questionnaire.
Where it's recruiting
Rochester
Source: ClinicalTrials.gov · NCT05499702 · last updated 2026-05-28