Benefits of Nicotinamide Riboside Upon Cognition and Sleep
Eligible age
65–85 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
Sponsor: State University of New York at Buffalo
You may qualify if…
- ✓ Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5
You may not qualify if…
- ✕ Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20
Where it's recruiting
Buffalo
Source: ClinicalTrials.gov · NCT05500170 · last updated 2025-08-22