RecruitingDiabetes MellitusDiabetes Mellitus ProgressionGlucose Intolerance

Rare and Atypical Diabetes Network

Eligible age

All ages

Accepts

All genders

Locations

12 states

Healthy volunteers

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About this study

RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes. 3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes.

Sponsor: University of South Florida

You may qualify if…

✓ The following criteria or phenotypes will be considered for suspecting "atypical" participants:
✓ Type 2 diabetes diagnosed at a time when the individual was prepubertal or non-obese
✓ Mendelian pattern, especially with early onset (\<18 years old)
✓ Syndromic (multiple systems involved)
✓ Lipodystrophic
✓ Extremes of BMI
✓ "Mitochondrial" characteristics (e.g., myopathy, hearing deficits)
✓ Non-progressive

You may not qualify if…

✕ Those with high likelihood of typical type 1, typical type 2, known monogenic, or other known secondary forms of diabetes
✕ Refusal of consent for genetic testing
✕ Islet autoantibody positive (participants who are islet autoantibody positive but present with additional atypical features i.e. syndromic, strong linear family history of diabetes may not be excluded)
✕ Women who are currently pregnant