Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
Eligible age
18–89 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).
Sponsor: University of Alabama at Birmingham
You may qualify if…
- ✓ 1. Male or Female, age 18-89
- ✓ 2. Chronic pain for more than 3 months
- ✓ 3. Willing to visit a research lab
- ✓ 4. Willing to undergo a blood draw
- ✓ 5. Able to provide written informed consent
You may not qualify if…
- ✕ 1. History of neurological disease (e.g., dementias, Parkinson's)
- ✕ 2. History of stroke
- ✕ 3. Current diagnosis of cancer
- ✕ 4. Subject is unwilling or unable to comply with the protocol
Where it's recruiting
Birmingham
Source: ClinicalTrials.gov · NCT05556902 · last updated 2026-08-11