Sleep Disordered Breathing With Opioid Use
Eligible age
18–89 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ Veterans, age 18-89 years
- ✓ Veterans with prescription opioids
You may not qualify if…
- ✕ Patients with BMI\>40kg/m2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
- ✕ Patients with history of unresolved/untreated cardiac disease, including recent myocardial infarction, recent bypass surgery, untreated atrial and ventricular tachy-bradycardias
- ✕ Congestive heart failure with Cheyne-Stokes respiration (CSR)
- ✕ Current unstable angina
- ✕ Recent stroke
- ✕ Untreated schizophrenia
- ✕ Untreated hypothyroidism
- ✕ Unresolved seizure disorder
Where it's recruiting
Detroit
Source: ClinicalTrials.gov · NCT05589753 · last updated 2025-07-18