Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Eligible age
18–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.
Sponsor: Medical College of Wisconsin
You may qualify if…
- ✓ Clinical Diagnosis of Type 2 Diabetes Mellitus in accordance with American Diabetes Association (ADA) guidelines (Type 2 Diabetic group)
- ✓ Otherwise healthy individuals (Healthy control group) with no more than 1 cardiovascular risk factor
You may not qualify if…
- ✕ Uncontrolled hypertension
- ✕ Current Tobacco use or within last 6 months
- ✕ BMI \> 35
- ✕ Hyperlipidemia
- ✕ Hypercholesterolemia
- ✕ Type 1 Diabetes
- ✕ Use of anti-coagulant drugs, or anti-platelet drugs
- ✕ Symptomatic coronary artery disease
Where it's recruiting
Milwaukee
Source: ClinicalTrials.gov · NCT05593549 · last updated 2025-10-30