Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Eligible age
18+ yrs
Accepts
All genders
Locations
41 states
Healthy volunteers
No
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About this study
The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC) which includes either pembrolizumab or pembrolizumab plus capecitabine in participants with triple negative breast cancer that still remains after surgery and pre-surgical treatment.
Sponsor: Gilead Sciences
Where it's recruiting
Birmingham · Huntsville
Glendale · Phoenix · Prescott Valley
Berkeley · Clovis · Downey · Fountain Valley …
Aurora
Danbury · Stamford
Washington D.C.
Clearwater · Gainesville · Jacksonville · Jupiter …
Athens · Atlanta · Marietta · Newnan …
Boise · Coeur d'Alene
Chicago · Evanston · Naperville · River Forest …
Indianapolis · Lafayette · Munster
Cedar Rapids · Des Moines · Iowa City
Source: ClinicalTrials.gov · NCT05633654 · last updated 2026-10-13