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RecruitingTriple Negative Breast Cancer

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

Eligible age

18+ yrs

Accepts

All genders

Locations

41 states

Healthy volunteers

No

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About this study

The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC) which includes either pembrolizumab or pembrolizumab plus capecitabine in participants with triple negative breast cancer that still remains after surgery and pre-surgical treatment.

Sponsor: Gilead Sciences

Where it's recruiting

Alabama

Birmingham · Huntsville

Arizona

Glendale · Phoenix · Prescott Valley

California

Berkeley · Clovis · Downey · Fountain Valley …

Colorado

Aurora

Connecticut

Danbury · Stamford

District of Columbia

Washington D.C.

Florida

Clearwater · Gainesville · Jacksonville · Jupiter …

Georgia

Athens · Atlanta · Marietta · Newnan …

Idaho

Boise · Coeur d'Alene

Illinois

Chicago · Evanston · Naperville · River Forest …

Indiana

Indianapolis · Lafayette · Munster

Iowa

Cedar Rapids · Des Moines · Iowa City

Source: ClinicalTrials.gov · NCT05633654 · last updated 2026-10-13