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RecruitingMigraine

Migraine in Adolescents

Eligible age

10–13 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset. Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset. Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.

Sponsor: Washington University School of Medicine

You may qualify if…

  • 1. Age 10-13
  • 2. Males or females (biological sex)
  • 3. Not diagnosed with migraine or having migraine symptoms
  • 4. With a first degree relative diagnosed with migraine (for the Fam-His group) or without a first or a second degree relative diagnosed with migraine (for the No-Fam-His group)
  • 1. Age 10-13
  • 2. Males or females (biological sex)
  • 3. Diagnosed with migraine or having migraine symptoms
  • 4. Migraine duration \> 6 months

You may not qualify if…

  • Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
  • 1. Diagnosis of any chronic pain syndrome
  • 2. Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder
  • 3. Taking pain or psychiatric medications regularly
  • 4. Having an MRI contraindication such as metal in the body or claustrophobia
  • 5. Not able to understand and communicate in English
  • Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
  • 1. Diagnosis of any chronic pain syndrome other than migraine

Where it's recruiting

Missouri

St Louis

Source: ClinicalTrials.gov · NCT05654012 · last updated 2025-08-13