Amplitude Titration to Improve ECT Clinical Outcomes
Eligible age
50+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2). H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-Verbal Fluency
Sponsor: University of New Mexico
You may qualify if…
- ✓ Diagnosis of major depressive disorder or bipolar II
- ✓ Clinical indications for ECT with right unilateral electrode placement
You may not qualify if…
- ✕ Defined neurological or neurodegenerative disorder (e.g., traumatic brain injury, epilepsy, Alzheimer's disease)
- ✕ Other psychiatric conditions (e.g., schizophrenia, bipolar I disorder)
- ✕ Current drug or alcohol use disorder (except for nicotine)
- ✕ Contraindications to MRI.
Where it's recruiting
Albuquerque
Source: ClinicalTrials.gov · NCT05699226 · last updated 2026-01-26