RecruitingMajor Depressive Disorder
Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
Eligible age
18–55 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as a stand-alone intervention for major depressive disorder
Sponsor: Kymberly Young
You may qualify if…
- ✓ ages 18 - 55
- ✓ primary diagnosis of MDD and are currently depressed
- ✓ able to give written informed consent prior to participation
- ✓ unmedicated OR are stable on an antidepressant regime (at least 4 weeks to ensure symptoms are stable). Effective medications will not be discontinued for the purposes of the study.
You may not qualify if…
- ✕ clinically significant or unstable cardiovascular, pulmonary, endocrine, neurological, gastrointestinal illness or unstable medical disorder
- ✕ Current severe DSM-V alcohol or substance use disorder, with the exception of nicotine or caffeine. Clinician will access subjects' alcohol and substance use on a case-by-case to determine whether specific cases of mild or moderate alcohol or substance use would also interfere with the effects of the intervention.
- ✕ history of traumatic brain injury
- ✕ unable to complete MRI scan due to claustrophobia or general MRI exclusions (e.g., shrapnel inside body)
- ✕ currently pregnant or breast feeding
- ✕ unable to complete questionnaires written in English
- ✕ current (within 3 weeks of testing) use of any antipsychotics, anticonvulsants, stimulants, benzodiazepines, beta-blockers, or other medications (except antidepressants) likely to influence cerebral blood flow. Effective medications will not be discontinued for the purposes of the study.
- ✕ diagnosis of psychotic or organic mental disorder, bipolar I or II disorder.
Where it's recruiting
Pennsylvania
Pittsburgh
Source: ClinicalTrials.gov · NCT05703256 · last updated 2026-03-04