RecruitingDepression
A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients
Eligible age
18–99 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
The purpose of this research is to study the effects of intravenous ketamine infusions for the treatment of patients with depressive symptoms in intensive care unit (ICU).
Sponsor: Mayo Clinic
You may qualify if…
- ✓ Has been in the Mayo Clinic Florida ICU for the past 1 week.
- ✓ PHQ-9 score of 10 or higher.
- ✓ One of the following diagnoses: acute myocardial infarction; acute renal failure; chronic obstructive pulmonary disease (COPD); congestive heart failure; end-stage liver disease; patients requiring intra-aortic balloon pump (IABP) therapy or continuous renal replacement therapy (CRRT); post-bone marrow transplant; acute Hypoxemic Respiratory Failure; acute or chronic hypoxemic respiratory failure; pre- or post- lung, liver or heart transplant or surgical overflows (such as abdominal aortic aneurysm, thoracotomy or tracheostomy).
You may not qualify if…
- ✕ Poor vital sign stability hypoxia: O2 \< 95%, hypotension: SBP \< 90 hypertension: SBP \> 180.
- ✕ Heart rate: \< 50 or \> 120, or Respiratory Rate: \< 10 or \> 30.
- ✕ Altered mental status.
- ✕ Patient is unwilling to participate or provide informed consent.
- ✕ Any allergy to ketamine or diphenhydramine.
- ✕ Patient is female of child-bearing age and unwilling to provide urine or blood for HCG analysis.
- ✕ Pregnant or breastfeeding.
- ✕ Presence of intracranial mass or vascular lesion.
Where it's recruiting
Florida
Jacksonville
Source: ClinicalTrials.gov · NCT05803551 · last updated 2025-08-08