RecruitingAlzheimer DiseaseAlzheimer Disease With DelusionsAlzheimer Disease With Psychosis

Tau Networks in Psychotic Alzheimer's Disease

Eligible age

65–85 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology. Amongst the cognitive manifestations of psychosis are impairments related to frontal circuits (social cognition, working memory and executive function deficits). The investigator's previous work suggests a role of tau pathology (one of the hallmarks of AD neuropathology) in the manifestation of psychosis in AD. However, the cerebral mechanisms that underly this association remain poorly understood. The overarching aim of the study is is to investigate the mechanisms by which tau network pathology may promote the presentation of psychosis in AD.

Sponsor: Northwell Health

You may qualify if…

✓ Age 65-85 years old.
✓ Diagnosis of probable AD dementia according to National Institute on Aging-Alzheimer's Association (NIA-AA) criteria.
✓ Mini-Mental State Examination (MMSE) score ≥ 10 and ≤ 26 at the screening visit.
✓ Clinical Dementia Rating (CDR) score ≥ 0.5.
✓ Logical Memory delay score of ≤8 for 16+ years of education, ≤4 for 8-15 years of education, and ≤2 for 0-7 years of education
✓ Age 65-85 years old.
✓ No known genetic risk factors for dementia.
✓ No cognitive complaint

You may not qualify if…

✕ Rosen-modified Hachinski Ischemia Score \> 4 at the screening visit.
✕ History of stroke.
✕ Evidence of a clinically relevant neurological disorder other than probable AD at the screening visit. Participants with insulin dependent type 2 diabetes, a history of CVD, a history of epilepsy, a history of TBI with greater than 15 minutes of loss of consciousness, a movement disorder, autoimmune disease affecting the CNS, or delirium.
✕ Evidence of a clinically relevant or unstable psychiatric disorder, based on DSM-5 criteria, including schizophrenia or other psychotic disorder, bipolar disorder, delirium, or current/active major depression.
✕ History of alcoholism or drug dependency/abuse within the last 5 years before screening.
✕ Presence of metal implants such as pacemakers, ear implants, internal bullet fragments or shrapnel.
✕ Inability to lie flat for 1 hour approximately.
✕ hearing impairment as evidenced by the inability to hear 500, 1000 and 6000 Hz bilaterally on an OAE evaluation. Subjects with hearing aides will be allowed to participate if they meet minimum hearing requirements.

Where it's recruiting

New York

Manhasset