A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Eligible age
65+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.
Sponsor: Arizona State University
You may qualify if…
- ✓ Participants:
- ✓ Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.
- ✓ Community-dwelling, e.g., homes and assisted living
- ✓ Age 65 years and older
- ✓ Medical clearance from PCP or cardiovascular provider
- ✓ Have a qualified study partner
- ✓ Agree to the blood draws
- ✓ Verified MRI safety
You may not qualify if…
- ✕ Participants
- ✕ Resting HR ≤ 50 or ≥ 100 beats/min after 5-minutes of quiet resting
- ✕ American College of Sports Medicine contraindications to exercise
- ✕ New, unevaluated symptoms or diseases a healthcare provider has not evaluated
- ✕ Abnormal cardiac condition uncovered during VO2peak testing
- ✕ Enrollment in another intervention that aims at improving cognition
- ✕ Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months
- ✕ ≥ 2 anti-depression medications, or poorly managed or unstable depression
Where it's recruiting
Phoenix
Source: ClinicalTrials.gov · NCT05877196 · last updated 2026-05-05