Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
Eligible age
50–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. \[exploratory\]
Sponsor: Massachusetts General Hospital
You may qualify if…
- ✓ Overall cognitive functional status consistent with amnesic MCI (CDR 0.5) likely due to AD (AD biomarker supported)
- ✓ 50-80 years of age
- ✓ English native speakers
You may not qualify if…
- ✕ Known presence of a structural brain lesion (e.g., tumor, cortical infarct)
- ✕ Acute or decompensated active medical conditions, including cancer, cardiovascular disease, stroke, congestive heart failure
- ✕ Active hematological, renal, pulmonary, endocrine or hepatic disorders
- ✕ Longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
- ✕ tACS contraindications (lesions in the scalp, history of seizures)
Where it's recruiting
Charlestown
Source: ClinicalTrials.gov · NCT05904132 · last updated 2025-06-12