RecruitingTreatment Resistant Depression
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Eligible age
21–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
Sponsor: Washington University School of Medicine
You may qualify if…
- ✓ Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.
You may not qualify if…
- ✕ Diagnoses of schizophrenia or schizoaffective disorders.
- ✕ Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.
Where it's recruiting
Missouri
St Louis
Source: ClinicalTrials.gov · NCT05905705 · last updated 2026-03-12