The Osteoarthritis Prevention Study
Eligible age
50+ yrs
Accepts
Women
Locations
2 states
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.
Sponsor: Wake Forest University
You may qualify if…
- ✓ Female
- ✓ BMI ≥ 30 kg/m2
- ✓ An eligible knee will have no OA by xray and MRI
- ✓ No or infrequent knee pain (\< 15 days/month) in the same knee
You may not qualify if…
- ✕ symptomatic or severe coronary artery disease
- ✕ unable to walk without a device
- ✕ blindness
- ✕ type 1 diabetes
- ✕ active treatment for cancer
- ✕ during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without surgical repair
- ✕ knee injection during the past 6 months
- ✕ bilateral knee OA by x-ray Kellgren-Lawrence (KL) ≥ 2
Where it's recruiting
Boston
Chapel Hill · Winston-Salem
Source: ClinicalTrials.gov · NCT05946044 · last updated 2025-07-23