90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
This clinical trial will compare 1-year outcomes in patients with hypoalbuminemia and a new diagnosis of small, early-stage hepatocellular carcinoma (HCC) who are candidates for both 90-Yittrium Therasphere transarterial radioembolization (90Y) and microwave ablation (MWA). The study will determine whether treatment with 90Y lowers the risk of disease progression within the first year after diagnosis. Participants will be randomized to receive either first cycle 90Y or MWA and then proceed with standard of care.
Sponsor: Ochsner Health System
You may qualify if…
- ✓ HCC diagnosis according to the Liver Imaging - Reporting Data System (LI-RADS) Criteria as defined in the American Association for the Study of Liver Diseases 2018 HCC practice guidelines
- ✓ Eastern Cooperative Oncology Group score 0 - 1
- ✓ Child-Pugh A - B
- ✓ Bilirubin \< 2.5 mg/dL
- ✓ Creatinine \< 2.0 mg/dL
- ✓ No prior liver-directed therapy or systemic therapy for HCC
- ✓ Solitary, unresectable HCC ≤ 3cm
- ✓ Albumin level \< 3.4 g/dL at HCC diagnosis
You may not qualify if…
- ✕ Pregnant women
- ✕ Concurrent malignancy
Where it's recruiting
New Orleans
Source: ClinicalTrials.gov · NCT05953961 · last updated 2025-08-03